Anti-MTF2 antibody (1-190) (STJ29157)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MTF2 (1-190) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MTF2 |
| Gene ID | 22823 |
| Uniprot ID | MTF2_HUMAN |
| Immunogen Region | 1-190 |
| Immunogen Sequence | MRDSTGAGNSLVHKRSPLRR NQKTPTSLTKLSLQDGHKAK KPACKFEEGQDVLARWSDGL FYLGTIKKINILKQSCFIIF EDSSKSWVLWKDIQTGATGS GEMVCTICQEEYSEAPNEMV ICDKCGQGYHQLCHTPHIDS SVIDSDEKWLCRQCVFATTT KRGGALKKGPNAKALQVMKQ TLPYSVADLE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human MTF2 (NP_001157864.1). |
Additional Info
| Function | Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter. |
| Protein Name | Metal-Response Element-Binding Transcription Factor 2Metal Regulatory Transcription Factor 2Metal-Response Element Dna-Binding Protein M96Polycomb-Like Protein 2Hpcl2 |
| Database Links | Reactome: R-HSA-212300 |
| Cellular Localisation | NucleusLocalizes To Chromatin As Part Of The Prc2 Complex |
| Alternative Antibody Names | Anti-Metal-Response Element-Binding Transcription Factor 2 antibodyAnti-Metal Regulatory Transcription Factor 2 antibodyAnti-Metal-Response Element Dna-Binding Protein M96 antibodyAnti-Polycomb-Like Protein 2 antibodyAnti-Hpcl2 antibodyAnti-MTF2 antibodyAnti-PCL2 antibody |
Information sourced from Uniprot.org