| Function | Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter. |
| Protein Name | Metal-Response Element-Binding Transcription Factor 2Metal Regulatory Transcription Factor 2Metal-Response Element Dna-Binding Protein M96Polycomb-Like Protein 2Hpcl2 |
| Database Links | Reactome: R-HSA-212300 |
| Cellular Localisation | NucleusLocalizes To Chromatin As Part Of The Prc2 Complex |
| Alternative Antibody Names | Anti-Metal-Response Element-Binding Transcription Factor 2 antibodyAnti-Metal Regulatory Transcription Factor 2 antibodyAnti-Metal-Response Element Dna-Binding Protein M96 antibodyAnti-Polycomb-Like Protein 2 antibodyAnti-Hpcl2 antibodyAnti-MTF2 antibodyAnti-PCL2 antibody |
Information sourced from Uniprot.org
