Anti-MSRB1 antibody (1-94) (STJ28820)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MSRB1 (1-94) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:100-1:500IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MSRB1 |
| Gene ID | 51734 |
| Uniprot ID | MSRB1_HUMAN |
| Immunogen Region | 1-94 |
| Immunogen Sequence | MSFCSFFGGEVFQNHFEPGV YVCAKCGYELFSSRSKYAHS SPWPAFTETIHADSVAKRPE HNRSEALKVSCGKCGNGLGH EFLNDGPKPGQSRF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-94 of human MSRB1 (NP_057416.1). |
Additional Info
| Post Translational Modifications | Truncated MSRB1/SEPX1 proteins produced by failed UGA/Sec decoding are ubiquitinated by some Cul2-RING E3 ubiquitin-protein ligase complexes (containing either PRAME, PRAMF6, PRAMF9 or FEM1C as substrate-recognition component). |
| Function | Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages. |
| Protein Name | Methionine-R-Sulfoxide Reductase B1Msrb1Selenoprotein XSelx |
| Database Links | Reactome: R-HSA-5676934 |
| Cellular Localisation | CytoplasmNucleusCytoskeleton |
| Alternative Antibody Names | Anti-Methionine-R-Sulfoxide Reductase B1 antibodyAnti-Msrb1 antibodyAnti-Selenoprotein X antibodyAnti-Selx antibodyAnti-MSRB1 antibodyAnti-SEPX1 antibodyAnti-HSPC270 antibody |
Information sourced from Uniprot.org