| Host: |
Rabbit |
| Applications: |
WB/IHC-P/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
OGA |
| Gene ID: |
10724 |
| Uniprot ID: |
OGA_HUMAN |
| Immunogen Region: |
380-580 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 380-580 of human MGEA5 (NP_001135906.1). |
| Immunogen Sequence: |
YQEPIMSQGAALSGEPTTLT KEEEKKQPDEEPMDMVVEKQ EETDHKNDNQILSEIVEAKM AEELKPMDTDKESIAESKSP EMSMQEDCISDIAPMQTDEQ TNKEQFVPGPNEKPLYTAEP VTLEDLQLLADLFYLPYEHG PKGAQMLREFQWLRANSSVV SVNCKGKDSEKIEEWRSRAA KFEEMCGLVMGMFTRLSNCA N |
| Tissue Specificity | Ubiquitous. Shows highest expression in the brain, placenta and pancreas. |
| Post Translational Modifications | Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other.cleavage does not decrease enzyme activity. |
| Function | Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity. Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. |
| Protein Name | Protein O-GlcnacaseOgaBeta-N-AcetylglucosaminidaseBeta-N-AcetylhexosaminidaseBeta-HexosaminidaseMeningioma-Expressed Antigen 5N-Acetyl-Beta-D-GlucosaminidaseN-Acetyl-Beta-GlucosaminidaseNuclear Cytoplasmic O-Glcnacase And AcetyltransferaseNcoat |
| Cellular Localisation | Isoform 3: NucleusIsoform 1: Cytoplasm |
| Alternative Antibody Names | Anti-Protein O-Glcnacase antibodyAnti-Oga antibodyAnti-Beta-N-Acetylglucosaminidase antibodyAnti-Beta-N-Acetylhexosaminidase antibodyAnti-Beta-Hexosaminidase antibodyAnti-Meningioma-Expressed Antigen 5 antibodyAnti-N-Acetyl-Beta-D-Glucosaminidase antibodyAnti-N-Acetyl-Beta-Glucosaminidase antibodyAnti-Nuclear Cytoplasmic O-Glcnacase And Acetyltransferase antibodyAnti-Ncoat antibodyAnti-OGA antibodyAnti-HEXC antibodyAnti-KIAA0679 antibodyAnti-MEA5 antibodyAnti-MGEA5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
