| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MGAT4A |
| Gene ID: | 11320 |
| Uniprot ID: | MGT4A_HUMAN |
| Immunogen Region: | 28-100 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-100 of human MGAT4A (NP_036346.1). |
| Immunogen Sequence: | QNGKEKLIAYQREFLALKER LRIAEHRISQRSSELNTIVQ QFKRVGAETNGSKDALNKFS DNTLKLLKELTSK |
| Tissue Specificity | Expressed in pancreas, spleen, thymus, prostate, small intestine, peripheral blood leukocytes and lymph node. Strongly overexpressed in choriocarcinoma cancer cell lines. Down-regulated in pancreatic cancer. |
| Post Translational Modifications | N-glycosylated. |
| Function | Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells. |
| Protein Name | Alpha-1 -3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase Iva Glcnac-T Iva Gnt-Iva N-Acetylglucosaminyltransferase Iva Udp-N-Acetylglucosamine - Alpha-1 -3-D-Mannoside Beta-1 -4-N-Acetylglucosaminyltransferase Iva Cleaved Into - Alpha-1 -3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A Soluble Form |
| Database Links | Reactome: R-HSA-381426 Reactome: R-HSA-8957275 Reactome: R-HSA-9694548 Reactome: R-HSA-975577 |
| Cellular Localisation | Alpha-1 3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A: Golgi Apparatus Membrane Single-Pass Type Ii Membrane Protein 3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A Soluble Form: Secreted |
| Alternative Antibody Names | Anti-Alpha-1 -3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A antibody Anti-N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase Iva antibody Anti-Glcnac-T Iva antibody Anti-Gnt-Iva antibody Anti-N-Acetylglucosaminyltransferase Iva antibody Anti-Udp-N-Acetylglucosamine - Alpha-1 -3-D-Mannoside Beta-1 -4-N-Acetylglucosaminyltransferase Iva Cleaved Into - Alpha-1 -3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase A Soluble Form antibody Anti-MGAT4A antibody |
Information sourced from Uniprot.org