| Tissue Specificity | Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed. |
| Function | Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed. |
| Protein Name | Melanoma-Associated Antigen D1Mage Tumor Antigen CcfMage-D1 AntigenNeurotrophin Receptor-Interacting Mage Homolog |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-418889Reactome: R-HSA-9768919 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinNucleusExpression Shifts From The Cytoplasm To The Plasma Membrane Upon Stimulation With Ngf |
| Alternative Antibody Names | Anti-Melanoma-Associated Antigen D1 antibodyAnti-Mage Tumor Antigen Ccf antibodyAnti-Mage-D1 Antigen antibodyAnti-Neurotrophin Receptor-Interacting Mage Homolog antibodyAnti-MAGED1 antibodyAnti-NRAGE antibodyAnti-PP2250 antibodyAnti-PRO2292 antibody |
Information sourced from Uniprot.org
