Anti-MAGED1 antibody (635-834) (STJ24447)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MAGED1 (635-834) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500IHC-P:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAGED1 |
| Gene ID | 9500 |
| Uniprot ID | MAGD1_HUMAN |
| Immunogen Region | 635-834 |
| Immunogen Sequence | EAVLWEALRKMGLRPGVRHP LLGDLRKLLTYEFVKQKYLD YRRVPNSNPPEYEFLWGLRS YHETSKMKVLRFIAEVQKRD PRDWTAQFMEAADEALDALD AAAAEAEARAEARTRMGIGD EAVSGPWSWDDIEFELLTWD EEGDFGDPWSRIPFTFWARY HQNARSRFPQTFAGPIIGPG GTASANFAANFGAIGFFWVE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 635-834 of human MAGED1/NRAGE (NP_001005333.1). |
Additional Info
| Tissue Specificity | Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed. |
| Function | Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed. |
| Protein Name | Melanoma-Associated Antigen D1Mage Tumor Antigen CcfMage-D1 AntigenNeurotrophin Receptor-Interacting Mage Homolog |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-418889Reactome: R-HSA-9768919 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinNucleusExpression Shifts From The Cytoplasm To The Plasma Membrane Upon Stimulation With Ngf |
| Alternative Antibody Names | Anti-Melanoma-Associated Antigen D1 antibodyAnti-Mage Tumor Antigen Ccf antibodyAnti-Mage-D1 Antigen antibodyAnti-Neurotrophin Receptor-Interacting Mage Homolog antibodyAnti-MAGED1 antibodyAnti-NRAGE antibodyAnti-PP2250 antibodyAnti-PRO2292 antibody |
Information sourced from Uniprot.org