| Host: | Rabbit |
| Applications: | IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KLHL42 |
| Gene ID: | 57542 |
| Uniprot ID: | KLH42_HUMAN |
| Immunogen Region: | 206-505 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 206-505 of human KLHL42 (NP_065833.1). |
| Immunogen Sequence: | PLAPHPYQGEPPSMLRYEEM TERWFPLANNLPPDLVNVRG YGSAILDNYLFIVGGYRITS QEISAAHSYNPSTNEWLQVA SMNQKRSNFKLVAVNSKLYA IGGQAVSNVECYNPEQDAWN FVAPLPNPLAEFSACECKGK IYVIGGYTTRDRNMNILQYC PSSDMWTLFETCDVHIRKQQ MVSVEETIYIVGGCLHELGP NRRSSQSEDMLTVQSYNTVT RQWLYLKENTSKSGLNLTC |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis. |
| Protein Name | Kelch-Like Protein 42 Cullin-3-Binding Protein 9 Ctb9 Kelch Domain-Containing Protein 5 |
| Database Links | Reactome: R-HSA-8951664 Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm Cytoskeleton Spindle Predominantly In Mitotic Cells Localized Diffusely In The Cytoplasm During The Interphase During Metaphase Is Localized Throughout The Cell And More Widely Dispersed Than The Microtubules In Anaphase Cells Is Localized Between The Two Sets Of Separated Chromosomes As Well As At The Spindle Poles During Telophase Is Localized Arround The Nuclei Of The Two Daughter Cells Not Detected At The Midbody Region During Cytokinesis |
| Alternative Antibody Names | Anti-Kelch-Like Protein 42 antibody Anti-Cullin-3-Binding Protein 9 antibody Anti-Ctb9 antibody Anti-Kelch Domain-Containing Protein 5 antibody Anti-KLHL42 antibody Anti-KIAA1340 antibody Anti-KLHDC5 antibody |
Information sourced from Uniprot.org