Anti-KLHL42 antibody (206-505) (STJ116406)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KLHL42 (206-505) antibody for use in IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KLHL42 |
| Gene ID | 57542 |
| Uniprot ID | KLH42_HUMAN |
| Immunogen Region | 206-505 |
| Immunogen Sequence | PLAPHPYQGEPPSMLRYEEM TERWFPLANNLPPDLVNVRG YGSAILDNYLFIVGGYRITS QEISAAHSYNPSTNEWLQVA SMNQKRSNFKLVAVNSKLYA IGGQAVSNVECYNPEQDAWN FVAPLPNPLAEFSACECKGK IYVIGGYTTRDRNMNILQYC PSSDMWTLFETCDVHIRKQQ MVSVEETIYIVGGCLHELGP NRRSSQSEDMLTVQSYNTVT RQWLYLKENTSKSGLNLTC |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 206-505 of human KLHL42 (NP_065833.1). |
Additional Info
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis. |
| Protein Name | Kelch-Like Protein 42Cullin-3-Binding Protein 9Ctb9Kelch Domain-Containing Protein 5 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytoskeletonSpindlePredominantly In Mitotic CellsLocalized Diffusely In The Cytoplasm During The InterphaseDuring Metaphase Is Localized Throughout The Cell And More Widely Dispersed Than The MicrotubulesIn Anaphase Cells Is Localized Between The Two Sets Of Separated Chromosomes As Well As At The Spindle PolesDuring Telophase Is Localized Arround The Nuclei Of The Two Daughter CellsNot Detected At The Midbody Region During Cytokinesis |
| Alternative Antibody Names | Anti-Kelch-Like Protein 42 antibodyAnti-Cullin-3-Binding Protein 9 antibodyAnti-Ctb9 antibodyAnti-Kelch Domain-Containing Protein 5 antibodyAnti-KLHL42 antibodyAnti-KIAA1340 antibodyAnti-KLHDC5 antibody |
Information sourced from Uniprot.org