| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KIRREL (17-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KIRREL1 |
| Gene ID: |
55243 |
| Uniprot ID: |
KIRR1_HUMAN |
| Immunogen Region: |
17-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 17-200 of human KIRREL (NP_060710.3). |
| Immunogen Sequence: |
QGTQTRFSQEPADQTVVAGQ RAVLPCVLLNYSGIVQWTKD GLALGMGQGLKAWPRYRVVG SADAGQYNLEITDAELSDDA SYECQATEAALRSRRAKLTV LIPPEDTRIDGGPVILLQAG TPHNLTCRAFNAKPAATIIW FRDGTQQEGAVASTELLKDG KRETTVSQLLINPTDLDIGR VFTC |
| Tissue Specificity | Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. |
| Post Translational Modifications | Phosphorylation probably regulates the interaction with NSH2. Phosphorylated at Tyr-605 and Tyr-606 by FYN, leading to GRB2 binding. N-glycosylated. |
| Function | Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm. It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. |
| Protein Name | Kin Of Irre-Like Protein 1Kin Of Irregular Chiasm-Like Protein 1Nephrin-Like Protein 1 |
| Database Links | Reactome: R-HSA-373753 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinPredominantly Located At Podocyte Slit Diaphragm |
| Alternative Antibody Names | Anti-Kin Of Irre-Like Protein 1 antibodyAnti-Kin Of Irregular Chiasm-Like Protein 1 antibodyAnti-Nephrin-Like Protein 1 antibodyAnti-KIRREL1 antibodyAnti-KIRREL antibodyAnti-NEPH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
