| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KIR2DL3 |
| Gene ID: | 3804 |
| Uniprot ID: | KI2L3_HUMAN |
| Immunogen Region: | 22-245 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-245 of human KIR2DL3 (NP_056952.2). |
| Immunogen Sequence: | HEGVHRKPSLLAHPGPLVKS EETVILQCWSDVRFQHFLLH REGKFKDTLHLIGEHHDGVS KANFSIGPMMQDLAGTYRCY GSVTHSPYQLSAPSDPLDIV ITGLYEKPSLSAQPGPTVLA GESVTLSCSSRSSYDMYHLS REGEAHERRFSAGPKVNGTF QADFPLGPATHGGTYRCFGS FRDSPYEWSNSSDPLLVSVT GNPSNSWPSPTEPSSETGNP RHLH |
| Function | Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis. |
| Protein Name | Killer Cell Immunoglobulin-Like Receptor 2dl3 Cd158 Antigen-Like Family Member B2 Kir-023gb Killer Inhibitory Receptor Cl 2-3 Nkat2a Nkat2b Natural Killer-Associated Transcript 2 Nkat-2 P58 Natural Killer Cell Receptor Clone Cl-6 P58 Nk Receptor Cl-6 P58.2 Mhc Class-I-Specific Nk Receptor Cd Antigen Cd158b2 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Killer Cell Immunoglobulin-Like Receptor 2dl3 antibody Anti-Cd158 Antigen-Like Family Member B2 antibody Anti-Kir-023gb antibody Anti-Killer Inhibitory Receptor Cl 2-3 antibody Anti-Nkat2a antibody Anti-Nkat2b antibody Anti-Natural Killer-Associated Transcript 2 antibody Anti-Nkat-2 antibody Anti-P58 Natural Killer Cell Receptor Clone Cl-6 antibody Anti-P58 Nk Receptor Cl-6 antibody Anti-P58.2 Mhc Class-I-Specific Nk Receptor antibody Anti-Cd Antigen Cd158b2 antibody Anti-KIR2DL3 antibody Anti-CD158B2 antibody Anti-KIRCL23 antibody Anti-NKAT2 antibody |
Information sourced from Uniprot.org