| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Kdm6a |
| Gene ID: | 22289 |
| Uniprot ID: | KDM6A_MOUSE |
| Immunogen Region: | 550-700 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 550-700 of mouse KDM6A (NP_033509.1). |
| Immunogen Sequence: | MPSVSQPGVHTACPRQTLAN GPFSAGHVPCSTSRTLGSTD TVLIGNNHVTGSGSNGNVPY LQRNAPTLPHNRTNLTSSTE EPWKNQLSNSTQGLHKGPSS HLAGPNGERPLSSTGPSQHL QAAGSGIQNQNGHPTLPSNS VTQGAALNHLS |
| Tissue Specificity | Expressed in brain, heart and spleen. |
| Function | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. |
| Protein Name | Lysine-Specific Demethylase 6a Histone Demethylase Utx Ubiquitously Transcribed Tpr Protein On The X Chromosome Ubiquitously Transcribed X Chromosome Tetratricopeptide Repeat Protein Histone H3-Trimethyl-L-Lysine(27 Demethylase 6a |
| Database Links | Reactome: R-MMU-3214842 Reactome: -MMU-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 6a antibody Anti-Histone Demethylase Utx antibody Anti-Ubiquitously Transcribed Tpr Protein On The X Chromosome antibody Anti-Ubiquitously Transcribed X Chromosome Tetratricopeptide Repeat Protein antibody Anti-Histone H3-Trimethyl-L-Lysine(27 Demethylase 6a antibody Anti-Kdm6a antibody Anti-Utx antibody |
Information sourced from Uniprot.org