| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KDM6A (550-700) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Kdm6a |
| Gene ID: |
22289 |
| Uniprot ID: |
KDM6A_MOUSE |
| Immunogen Region: |
550-700 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 550-700 of mouse KDM6A (NP_033509.1). |
| Immunogen Sequence: |
MPSVSQPGVHTACPRQTLAN GPFSAGHVPCSTSRTLGSTD TVLIGNNHVTGSGSNGNVPY LQRNAPTLPHNRTNLTSSTE EPWKNQLSNSTQGLHKGPSS HLAGPNGERPLSSTGPSQHL QAAGSGIQNQNGHPTLPSNS VTQGAALNHLS |
| Tissue Specificity | Expressed in brain, heart and spleen. |
| Function | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. |
| Protein Name | Lysine-Specific Demethylase 6aHistone Demethylase UtxUbiquitously Transcribed Tpr Protein On The X ChromosomeUbiquitously Transcribed X Chromosome Tetratricopeptide Repeat ProteinHistone H3-Trimethyl-L-Lysine(27 Demethylase 6a |
| Database Links | Reactome: R-MMU-3214842Reactome: -MMU-9772755 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 6a antibodyAnti-Histone Demethylase Utx antibodyAnti-Ubiquitously Transcribed Tpr Protein On The X Chromosome antibodyAnti-Ubiquitously Transcribed X Chromosome Tetratricopeptide Repeat Protein antibodyAnti-Histone H3-Trimethyl-L-Lysine(27 Demethylase 6a antibodyAnti-Kdm6a antibodyAnti-Utx antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using [KO Validated] NCOA2 Rabbit polyclonal antibody (STJ112318) at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/92369/372743/STJ112318_1__72291.1713138814.jpg?c=1 "Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using [KO Validated] NCOA2 Rabbit polyclonal antibody (STJ112318) at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.")
