Anti-JPT1 antibody (STJA0007735)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human HN1
General Information
| Short Description | Rabbit polyclonal anti-Jupiter microtubule associated homolog 1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | JPT1 |
| Gene ID | 51155 |
| Uniprot ID | JUPI1_HUMAN |
| Immunogen | Synthesized peptide derived from human HN1 |
| Specificity | This antibody detects endogenous levels of HN1 at Human, Mouse, Rat |
Additional Info
| Function | Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation. |
| Protein Name | Jupiter Microtubule Associated Homolog 1Androgen-Regulated Protein 2Hematological And Neurological Expressed 1 Protein Cleaved Into - Jupiter Microtubule Associated Homolog 1 - N-Terminally Processed |
| Database Links | |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Jupiter Microtubule Associated Homolog 1 antibodyAnti-Androgen-Regulated Protein 2 antibodyAnti-Hematological And Neurological Expressed 1 Protein Cleaved Into - Jupiter Microtubule Associated Homolog 1 - N-Terminally Processed antibodyAnti-JPT1 antibodyAnti-ARM2 antibodyAnti-HN1 antibody |
Information sourced from Uniprot.org