Anti-HMBOX1 antibody (169-219 aa) (STJ194892)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human HMBX1 at the amino acid range 169-219
General Information
| Short Description | Rabbit polyclonal anti-Homeobox-containing protein 1 (169-219 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HMBOX1 |
| Gene ID | 79618 |
| Uniprot ID | HMBX1_HUMAN |
| Immunogen | Synthesized peptide derived from the human HMBX1 at the amino acid range 169-219 |
| Immunogen Region | 169-219 aa |
| Specificity | This antibody detects endogenous levels of HMBX1 at Human/Mouse |
Additional Info
| Function | Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation. Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination. Might also be involved in the DNA damage response at telomeres. |
| Protein Name | Homeobox-Containing Protein 1Homeobox Telomere-Binding Protein 1Telomere-Associated Homeobox-Containing Protein 1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmChromosomeTelomereCajal BodyPml BodyPredominantly Detected In CytoplasmLocalizes In A Dynamic Manner To Actively Processed TelomeresLocalizes To The Periphery Of Cajal BodiesAssociates With Pml Nuclear Bodies In Telomerase-Negative CellsIsoform 5: Nucleus |
| Alternative Antibody Names | Anti-Homeobox-Containing Protein 1 antibodyAnti-Homeobox Telomere-Binding Protein 1 antibodyAnti-Telomere-Associated Homeobox-Containing Protein 1 antibodyAnti-HMBOX1 antibodyAnti-HOT1 antibodyAnti-TAH1 antibody |
Information sourced from Uniprot.org