| Function | Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation. Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination. Might also be involved in the DNA damage response at telomeres. |
| Protein Name | Homeobox-Containing Protein 1Homeobox Telomere-Binding Protein 1Telomere-Associated Homeobox-Containing Protein 1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmChromosomeTelomereCajal BodyPml BodyPredominantly Detected In CytoplasmLocalizes In A Dynamic Manner To Actively Processed TelomeresLocalizes To The Periphery Of Cajal BodiesAssociates With Pml Nuclear Bodies In Telomerase-Negative CellsIsoform 5: Nucleus |
| Alternative Antibody Names | Anti-Homeobox-Containing Protein 1 antibodyAnti-Homeobox Telomere-Binding Protein 1 antibodyAnti-Telomere-Associated Homeobox-Containing Protein 1 antibodyAnti-HMBOX1 antibodyAnti-HOT1 antibodyAnti-TAH1 antibody |
Information sourced from Uniprot.org
