| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Homeobox-containing protein 1 (169-219 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HMBOX1 |
| Gene ID: |
79618 |
| Uniprot ID: |
HMBX1_HUMAN |
| Immunogen Region: |
169-219 aa |
| Specificity: |
This antibody detects endogenous levels of HMBX1 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human HMBX1 at the amino acid range 169-219 |
| Function | Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA. Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation. Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination. Might also be involved in the DNA damage response at telomeres. |
| Protein Name | Homeobox-Containing Protein 1Homeobox Telomere-Binding Protein 1Telomere-Associated Homeobox-Containing Protein 1 |
| Cellular Localisation | NucleusCytoplasmChromosomeTelomereCajal BodyPml BodyPredominantly Detected In CytoplasmLocalizes In A Dynamic Manner To Actively Processed TelomeresLocalizes To The Periphery Of Cajal BodiesAssociates With Pml Nuclear Bodies In Telomerase-Negative CellsIsoform 5: Nucleus |
| Alternative Antibody Names | Anti-Homeobox-Containing Protein 1 antibodyAnti-Homeobox Telomere-Binding Protein 1 antibodyAnti-Telomere-Associated Homeobox-Containing Protein 1 antibodyAnti-HMBOX1 antibodyAnti-HOT1 antibodyAnti-TAH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
