| Post Translational Modifications | Phosphorylated at Ser-967 by CDK2 during the G1/S transition, resulting in its nuclear export into the cytoplasm. As S phase progresses, its exclusion from the nucleus promotes the activation of long-range resection. |
| Function | 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress. |
| Protein Name | Dna Helicase BHdhb |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmChromosomePredominantly NuclearPhosphorylation At Ser-967 By Cdk2 During The G1/S Transition Results In Its Nuclear Export Into The Cytoplasm As Cells Approach And Progress Through S PhaseFollowing Dna DamageRecruited To Sites Of Double-Strand Breaks By The Rpa ComplexRecruited To Chromatin Following Dna Damage Induced By Uv IrradiationOr Camptothecin Or Hydroxyurea Treatment |
| Alternative Antibody Names | Anti-Dna Helicase B antibodyAnti-Hdhb antibodyAnti-HELB antibody |
Information sourced from Uniprot.org
