Immunohistochemistry analysis of HCAR3 in paraffin-embedded Human spleen using HCAR3 Rabbit polyclonal antibody (STJ11100354) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.

Anti-HCAR3 antibody (300-392) (STJ11100354)

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STJ11100354
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Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HCAR3
Gene ID: 8843
Uniprot ID: HCAR3_HUMAN
Immunogen Region: 300-392
Specificity: A synthetic peptide corresponding to a sequence within amino acids 300-392 of human HCAR3 (NP_006009.2).
Immunogen Sequence: SFPNFFSTLINRCLQRKITG EPDNNRSTSVELTGDPNKTR GAPEALIANSGEPWSPSYLG PTSNNHSKKGHCHQEPASLE KQLGCCIE
Tissue Specificity Expression largely restricted to adipose tissue and spleen.
Function Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
Protein Name Hydroxycarboxylic Acid Receptor 3
G-Protein Coupled Receptor 109b
G-Protein Coupled Receptor Hm74
G-Protein Coupled Receptor Hm74b
Niacin Receptor 2
Nicotinic Acid Receptor 2
Database Links Reactome: R-HSA-3296197
Reactome: R-HSA-418594
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Hydroxycarboxylic Acid Receptor 3 antibody
Anti-G-Protein Coupled Receptor 109b antibody
Anti-G-Protein Coupled Receptor Hm74 antibody
Anti-G-Protein Coupled Receptor Hm74b antibody
Anti-Niacin Receptor 2 antibody
Anti-Nicotinic Acid Receptor 2 antibody
Anti-HCAR3 antibody
Anti-GPR109B antibody
Anti-HCA3 antibody
Anti-HM74B antibody
Anti-NIACR2 antibody

Information sourced from Uniprot.org

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