Anti-HCAR3 antibody (300-392) (STJ11100354)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HCAR3 (300-392) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HCAR3 |
| Gene ID | 8843 |
| Uniprot ID | HCAR3_HUMAN |
| Immunogen Region | 300-392 |
| Immunogen Sequence | SFPNFFSTLINRCLQRKITG EPDNNRSTSVELTGDPNKTR GAPEALIANSGEPWSPSYLG PTSNNHSKKGHCHQEPASLE KQLGCCIE |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 300-392 of human HCAR3 (NP_006009.2). |
Additional Info
| Tissue Specificity | Expression largely restricted to adipose tissue and spleen. |
| Function | Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. |
| Protein Name | Hydroxycarboxylic Acid Receptor 3G-Protein Coupled Receptor 109bG-Protein Coupled Receptor Hm74G-Protein Coupled Receptor Hm74bNiacin Receptor 2Nicotinic Acid Receptor 2 |
| Database Links | Reactome: R-HSA-3296197Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Hydroxycarboxylic Acid Receptor 3 antibodyAnti-G-Protein Coupled Receptor 109b antibodyAnti-G-Protein Coupled Receptor Hm74 antibodyAnti-G-Protein Coupled Receptor Hm74b antibodyAnti-Niacin Receptor 2 antibodyAnti-Nicotinic Acid Receptor 2 antibodyAnti-HCAR3 antibodyAnti-GPR109B antibodyAnti-HCA3 antibodyAnti-HM74B antibodyAnti-NIACR2 antibody |
Information sourced from Uniprot.org