| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HACE1 (1-100) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HACE1 |
| Gene ID: |
57531 |
| Uniprot ID: |
HACE1_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HACE1 (NP_065822.2). |
| Immunogen Sequence: |
MERAMEQLNRLTRSLRRART VELPEDNETAVYTLMPMVMA DQHRSVSELLSNSKFDVNYA FGRVKRSLLHIAANCGSVEC LVLLLKKGANPNYQDISGCT |
| Tissue Specificity | Expressed in multiple tissues including heart, brain and kidney. |
| Function | E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. |
| Protein Name | E3 Ubiquitin-Protein Ligase Hace1Hect Domain And Ankyrin Repeat-Containing E3 Ubiquitin-Protein Ligase 1Hect-Type E3 Ubiquitin Transferase Hace1 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneCytoplasmEndoplasmic ReticulumA Significant Portion Localizes To The Endoplasmic ReticulumTargeted To Golgi Membrane Via Its Interaction With Rab Proteins |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Hace1 antibodyAnti-Hect Domain And Ankyrin Repeat-Containing E3 Ubiquitin-Protein Ligase 1 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Hace1 antibodyAnti-HACE1 antibodyAnti-KIAA1320 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
