||Human, Mouse, Rat
||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-HACE1 (1-100) is suitable for use in Western Blot and Immunohistochemistry.
||PBS containing 0.02% Sodium Azide, 50% Glycerol, pH7.3.
||WB 1:500-1:2000IHC 1:50-1:200
||Store in a freezer at-20°C and avoid freeze-thaw cycles.
||A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HACE1 (NP_065822.2).
| Tissue Specificity || Expressed in multiple tissues including heart, brain and kidney. |
| Function || E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB. |
| Protein Name || E3 Ubiquitin-Protein Ligase Hace1Hect Domain And Ankyrin Repeat-Containing E3 Ubiquitin-Protein Ligase 1Hect-Type E3 Ubiquitin Transferase Hace1 |
| Database Links || Reactome: R-HSA-983168 |
| Cellular Localisation || Golgi ApparatusGolgi Stack MembraneCytoplasmEndoplasmic ReticulumA Significant Portion Localizes To The Endoplasmic ReticulumTargeted To Golgi Membrane Via Its Interaction With Rab Proteins |
| Alternative Antibody Names || Anti-E3 Ubiquitin-Protein Ligase Hace1 antibodyAnti-Hect Domain And Ankyrin Repeat-Containing E3 Ubiquitin-Protein Ligase 1 antibodyAnti-Hect-Type E3 Ubiquitin Transferase Hace1 antibodyAnti-HACE1 antibodyAnti-KIAA1320 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance