Host: |
Rabbit |
Applications: |
WB |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-GRK6 (268-465) is suitable for use in Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:2000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
GRK6 |
Gene ID: |
2870 |
Uniprot ID: |
GRK6_HUMAN |
Immunogen Region: |
268-465 |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 268-465 of human GRK6 (NP_001004106.1). |
Immunogen Sequence: |
GGDLKFHIYHMGQAGFPEAR AVFYAAEICCGLEDLHRERI VYRDLKPENILLDDHGHIRI SDLGLAVHVPEGQTIKGRVG TVGYMAPEVVKNERYTFSPD WWALGCLLYEMIAGQSPFQQ RKKKIKREEVERLVKEVPEE YSERFSPQARSLCSQLLCKD PAERLGCRGGSAREVKEHPL FKKLNFKRLGAGMLEPPF |
Tissue Specificity | Widely expressed. |
Post Translational Modifications | It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565. |
Function | Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). |
Protein Name | G Protein-Coupled Receptor Kinase 6G Protein-Coupled Receptor Kinase Grk6 |
Database Links | Reactome: R-HSA-418555 |
Cellular Localisation | MembraneLipid-Anchor |
Alternative Antibody Names | Anti-G Protein-Coupled Receptor Kinase 6 antibodyAnti-G Protein-Coupled Receptor Kinase Grk6 antibodyAnti-GRK6 antibodyAnti-GPRK6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance