Anti-GRK6 antibody (268-465) (STJ28462)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GRK6 (268-465) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GRK6 |
| Gene ID | 2870 |
| Uniprot ID | GRK6_HUMAN |
| Immunogen Region | 268-465 |
| Immunogen Sequence | GGDLKFHIYHMGQAGFPEAR AVFYAAEICCGLEDLHRERI VYRDLKPENILLDDHGHIRI SDLGLAVHVPEGQTIKGRVG TVGYMAPEVVKNERYTFSPD WWALGCLLYEMIAGQSPFQQ RKKKIKREEVERLVKEVPEE YSERFSPQARSLCSQLLCKD PAERLGCRGGSAREVKEHPL FKKLNFKRLGAGMLEPPF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 268-465 of human GRK6 (NP_001004106.1). |
Additional Info
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565. |
| Function | Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). |
| Protein Name | G Protein-Coupled Receptor Kinase 6G Protein-Coupled Receptor Kinase Grk6 |
| Database Links | Reactome: R-HSA-418555 |
| Cellular Localisation | MembraneLipid-Anchor |
| Alternative Antibody Names | Anti-G Protein-Coupled Receptor Kinase 6 antibodyAnti-G Protein-Coupled Receptor Kinase Grk6 antibodyAnti-GRK6 antibodyAnti-GPRK6 antibody |
Information sourced from Uniprot.org