| Tissue Specificity | Retinal-specific. Expressed in rods and cones cells. |
| Post Translational Modifications | Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492. Phosphorylation at Ser-21 is regulated by light and activated by cAMP. Farnesylation is required for full activity. |
| Function | Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. May play a role in the maintenance of the outer nuclear layer in the retina. |
| Protein Name | Rhodopsin Kinase Grk1RkG Protein-Coupled Receptor Kinase 1 |
| Database Links | Reactome: R-HSA-2514859 |
| Cellular Localisation | MembraneLipid-AnchorCell ProjectionCiliumPhotoreceptor Outer SegmentSubcellular Location Is Not Affected By Light Or Dark Conditions |
| Alternative Antibody Names | Anti-Rhodopsin Kinase Grk1 antibodyAnti-Rk antibodyAnti-G Protein-Coupled Receptor Kinase 1 antibodyAnti-GRK1 antibodyAnti-RHOK antibody |
Information sourced from Uniprot.org
