| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLA2 (1-160) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLA2 |
| Gene ID: |
84174 |
| Uniprot ID: |
SLAP2_HUMAN |
| Immunogen Region: |
1-160 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SLA2 (NP_115590.1). |
| Immunogen Sequence: |
MGSLPSRRKSLPSPSLSSSV QGQGPVTMEAERSKATAVAL GSFPAGGPAELSLRLGEPLT IVSEDGDWWTVLSEVSGREY NIPSVHVAKVSHGWLYEGLS REKAEELLLLPGNPGGAFLI RESQTRRGSYSLSVRLSRPA SWDRIRHYRIHCLDNGWLYI |
| Tissue Specificity | Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon. |
| Post Translational Modifications | Phosphorylated by CSF1R. |
| Function | Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. |
| Protein Name | Src-Like-Adapter 2Modulator Of Antigen Receptor SignalingMarsSrc-Like Adapter Protein 2Slap-2 |
| Database Links | Reactome: R-HSA-9706369 |
| Cellular Localisation | CytoplasmIsoform 1: Cell MembraneCytoplasmic VesicleLocalized To The Plasma Membrane And Intracellular VesiclesIncluding Late Endosomal VesiclesIsoform 2: CytoplasmMay Be Cytoplasmic And Is Not Localized To Membranes |
| Alternative Antibody Names | Anti-Src-Like-Adapter 2 antibodyAnti-Modulator Of Antigen Receptor Signaling antibodyAnti-Mars antibodyAnti-Src-Like Adapter Protein 2 antibodyAnti-Slap-2 antibodyAnti-SLA2 antibodyAnti-C20orf156 antibodyAnti-SLAP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
