| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GRK1 (1-160) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GRK1 |
| Gene ID: |
6011 |
| Uniprot ID: |
GRK1_HUMAN |
| Immunogen Region: |
1-160 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human GRK1 (NP_002920.1). |
| Immunogen Sequence: |
MDFGSLETVVANSAFIAARG SFDGSSSQPSRDKKYLAKLK LPPLSKCESLRDSLSLEFES VCLEQPIGKKLFQQFLQSAE KHLPALELWKDIEDYDTADN DLQPQKAQTILAQYLDPQAK LFCSFLDEGIVAKFKEGPVE IQDGLFQPLLQATLAHLGQA |
| Tissue Specificity | Retinal-specific. Expressed in rods and cones cells. |
| Post Translational Modifications | Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492. Phosphorylation at Ser-21 is regulated by light and activated by cAMP. Farnesylation is required for full activity. |
| Function | Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. May play a role in the maintenance of the outer nuclear layer in the retina. |
| Protein Name | Rhodopsin Kinase Grk1RkG Protein-Coupled Receptor Kinase 1 |
| Database Links | Reactome: R-HSA-2514859 |
| Cellular Localisation | MembraneLipid-AnchorCell ProjectionCiliumPhotoreceptor Outer SegmentSubcellular Location Is Not Affected By Light Or Dark Conditions |
| Alternative Antibody Names | Anti-Rhodopsin Kinase Grk1 antibodyAnti-Rk antibodyAnti-G Protein-Coupled Receptor Kinase 1 antibodyAnti-GRK1 antibodyAnti-RHOK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
