Anti-HSPB6 antibody (1-160) (STJ111929)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal HSPB6 (1-160) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HSPB6 |
| Gene ID | 126393 |
| Uniprot ID | HSPB6_HUMAN |
| Immunogen Region | 1-160 |
| Immunogen Sequence | MEIPVPVQPSWLRRASAPLP GLSAPGRLFDQRFGEGLLEA ELAALCPTTLAPYYLRAPSV ALPVAQVPTDPGHFSVLLDV KHFSPEEIAVKVVGEHVEVH ARHEERPDEHGFVAREFHRR YRLPPGVDPAAVTSALSPEG VLSIQAAPASAQAPPPAAAK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human HSP20/HSP20/HSPB6 (NP_653218.1). |
Additional Info
| Post Translational Modifications | The N-terminus is blocked. Phosphorylated at Ser-16 by PKA and probably PKD1K.required to protect cardiomyocytes from apoptosis. |
| Function | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. |
| Protein Name | Heat Shock Protein Beta-6Hspb6Heat Shock 20 Kda-Like Protein P20Heat Shock Protein Family B Member 6 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusSecretedTranslocates To Nuclear Foci During Heat Shock |
| Alternative Antibody Names | Anti-Heat Shock Protein Beta-6 antibodyAnti-Hspb6 antibodyAnti-Heat Shock 20 Kda-Like Protein P20 antibodyAnti-Heat Shock Protein Family B Member 6 antibodyAnti-HSPB6 antibody |
Information sourced from Uniprot.org