| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GPR62 |
| Gene ID: | 118442 |
| Uniprot ID: | GPR62_HUMAN |
| Immunogen Region: | 150-250 |
| Immunogen Sequence: | GTPPAPPPAPARCSVLAGGL GPFRPLWALLAFALPALLLL GAYGGIFVVARRAALRPPRP ARGSRLHSDSLDSRLSILPP LRPRLPGGKAALAPALAVGQ F |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human GPR62 (NP_543141.3). |
| Tissue Specificity | Expressed in brain.detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus. |
| Function | Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways. Has spontaneous activity for beta-arrestin recruitment. Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization. |
| Protein Name | G-Protein Coupled Receptor 62G-Protein Coupled Receptor Gpcr8Hgpcr8G-Protein Coupled Receptor Kpg_005 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndosome MembraneColocalizes With Arrb2 In The Endosome |
| Alternative Antibody Names | Anti-G-Protein Coupled Receptor 62 antibodyAnti-G-Protein Coupled Receptor Gpcr8 antibodyAnti-Hgpcr8 antibodyAnti-G-Protein Coupled Receptor Kpg_005 antibodyAnti-GPR62 antibody |
Information sourced from Uniprot.org
