| Host: |
Chicken |
| Applications: |
ELISA/WB/IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Chicken polyclonal antibody anti-GFRa-3 is suitable for use in ELISA, Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgY |
| Formulation: |
Concentrated ammonium sulphate in PBS pH 7.4 |
| Purification: |
GFR Alpha-3 affinity purified |
| Dilution Range: |
WB 1 to 2 µg/ml; ELISA 3 to 6.25 ng/ml; IF 0.3 to 0.67 µg/ml.Polyclonal antibody working titer has to be established practically for each particular antigen and assay format |
| Storage Instruction: |
Store at +4°C upon receipt. As product is (NH4) 2SO4 precipitate, mix well by pipetting or vortexing prior use |
| Gene Symbol: |
GFRA3 |
| Gene ID: |
2676 |
| Uniprot ID: |
GFRA3_HUMAN |
| Specificity: |
Human GFRa-3, doesn t cross-react with hGFRa-1, hGFRa-2, hGFRa-4 |
| Immunogen: |
Recombinant His-tagged human GFRa-3 protein produced using CHO-based proprietary suspension cell line. For production of hGFRa-3, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein w |
| Tissue Specificity | Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system. |
| Post Translational Modifications | N-glycosylated. |
| Function | Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. |
| Protein Name | Gdnf Family Receptor Alpha-3Gdnf Receptor Alpha-3Gdnfr-Alpha-3Gfr-Alpha-3 |
| Database Links | Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-3 antibodyAnti-Gdnf Receptor Alpha-3 antibodyAnti-Gdnfr-Alpha-3 antibodyAnti-Gfr-Alpha-3 antibodyAnti-GFRA3 antibodyAnti-UNQ339 antibodyAnti-PRO538 antibodyAnti-PRO3664 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
