Anti-GFRa-3 antibody (STJA0002879)

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STJA0002879
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Short Description :Chicken polyclonal anti-GFRa-3 for use in ELISA, WB and IF in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:ELISA/WB/IF
Host:Chicken
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgY
Conjugation:Unconjugated
Purification:GFR Alpha-3 affinity purified
Dilution Range:WB 1 to 2 µg/ml; ELISA 3 to 6.25 ng/ml; IF 0.3 to 0.67 µg/ml.Polyclonal antibody working titer has to be established practically for each particular antigen and assay format
Formulation:Concentrated ammonium sulphate in PBS pH 7.4
Storage Instruction:Store at +4°C upon receipt. As product is (NH4) 2SO4 precipitate, mix well by pipetting or vortexing prior use
Gene Symbol:GFRA3
Gene ID:2676
Uniprot ID:GFRA3_HUMAN
Immunogen:Recombinant His-tagged human GFRa-3 protein produced using CHO-based proprietary suspension cell line. For production of hGFRa-3, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein w
Specificity:Human GFRa-3, doesn t cross-react with hGFRa-1, hGFRa-2, hGFRa-4
Tissue Specificity Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.
Post Translational Modifications N-glycosylated.
Function Receptor for artemin (ARTN), a growth factor that supports the survival of sensory and sympathetic peripheral neurons. ARTN-binding leads to autophosphorylation and activation of the RET receptor.
Protein Name Gdnf Family Receptor Alpha-3
Gdnf Receptor Alpha-3
Gdnfr-Alpha-3
Gfr-Alpha-3
Database Links Reactome: R-HSA-5673001
Reactome: R-HSA-8853659
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Alternative Antibody Names Anti-Gdnf Family Receptor Alpha-3 antibody
Anti-Gdnf Receptor Alpha-3 antibody
Anti-Gdnfr-Alpha-3 antibody
Anti-Gfr-Alpha-3 antibody
Anti-GFRA3 antibody
Anti-UNQ339 antibody
Anti-PRO538 antibody
Anti-PRO3664 antibody

Information sourced from Uniprot.org

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