Anti-GFRa-3 antibody (STJA0002879)
SPECIFICATIONS
ClonalityPolyclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenRecombinant His-tagged human GFRa-3 protein produced using CHO-based proprietary suspension cell line. For production of hGFRa-3, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein w
General Information
| Short Description | Chicken polyclonal anti-GFRa-3 for use in ELISA, WB and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/IF |
| Host | Chicken |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Purification | GFR Alpha-3 affinity purified |
| Dilution Range | WB 1 to 2 ยตg/ml; ELISA 3 to 6.25 ng/ml; IF 0.3 to 0.67 ยตg/ml.Polyclonal antibody working titer has to be established practically for each particular antigen and assay format |
| Formulation | Concentrated ammonium sulphate in PBS pH 7.4 |
| Storage Instruction | Store at +4ยฐC upon receipt. As product is (NH4) 2SO4 precipitate, mix well by pipetting or vortexing prior use |
Target Information
| Gene Symbol | GFRA3 |
| Gene ID | 2676 |
| Uniprot ID | GFRA3_HUMAN |
| Immunogen | Recombinant His-tagged human GFRa-3 protein produced using CHO-based proprietary suspension cell line. For production of hGFRa-3, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein w |
| Specificity | Human GFRa-3, doesn t cross-react with hGFRa-1, hGFRa-2, hGFRa-4 |
Additional Info
| Tissue Specificity | Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system. |
| Post Translational Modifications | N-glycosylated. |
| Function | Receptor for artemin (ARTN), a growth factor that supports the survival of sensory and sympathetic peripheral neurons. ARTN-binding leads to autophosphorylation and activation of the RET receptor. |
| Protein Name | Gdnf Family Receptor Alpha-3Gdnf Receptor Alpha-3Gdnfr-Alpha-3Gfr-Alpha-3 |
| Database Links | Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-3 antibodyAnti-Gdnf Receptor Alpha-3 antibodyAnti-Gdnfr-Alpha-3 antibodyAnti-Gfr-Alpha-3 antibodyAnti-GFRA3 antibodyAnti-UNQ339 antibodyAnti-PRO538 antibodyAnti-PRO3664 antibody |
Information sourced from Uniprot.org