Anti-FTSJ3 antibody (608-847) (STJ112035)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FTSJ3 (608-847) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FTSJ3 |
| Gene ID | 117246 |
| Uniprot ID | SPB1_HUMAN |
| Immunogen Region | 608-847 |
| Immunogen Sequence | EGEEKDGISDSDSSTSSEEE ESWEPLRGKKRSRGPKSDDD GFEIVPIEDPAKHRILDPEG LALGAVIASSKKAKRDLIDN SFNRYTFNEDEGELPEWFVQ EEKQHRIRQLPVGKKEVEHY RKRWREINARPIKKVAEAKA RKKRRMLKRLEQTRKKAEAV VNTVDISEREKVAQLRSLYK KAGLGKEKRHVTYVVAKKGV GRKVRRPAGVRGHFKVVDSR MKKDQRAQQRKEQKKKHKR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 608-847 of human FTSJ3 (NP_060117.3). |
Additional Info
| Post Translational Modifications | Citrullinated by PADI4. |
| Function | RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system. RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5. Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine. Recruited to HIV-1 RNA via interaction with TARBP2/TRBP. |
| Protein Name | Pre-Rrna 2'-O-Ribose Rna Methyltransferase Ftsj3Protein Ftsj Homolog 3Putative Rrna Methyltransferase 3 |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Pre-Rrna 2'-O-Ribose Rna Methyltransferase Ftsj3 antibodyAnti-Protein Ftsj Homolog 3 antibodyAnti-Putative Rrna Methyltransferase 3 antibodyAnti-FTSJ3 antibodyAnti-SB92 antibody |
Information sourced from Uniprot.org