| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FTSJ3 (608-847) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FTSJ3 |
| Gene ID: |
117246 |
| Uniprot ID: |
SPB1_HUMAN |
| Immunogen Region: |
608-847 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 608-847 of human FTSJ3 (NP_060117.3). |
| Immunogen Sequence: |
EGEEKDGISDSDSSTSSEEE ESWEPLRGKKRSRGPKSDDD GFEIVPIEDPAKHRILDPEG LALGAVIASSKKAKRDLIDN SFNRYTFNEDEGELPEWFVQ EEKQHRIRQLPVGKKEVEHY RKRWREINARPIKKVAEAKA RKKRRMLKRLEQTRKKAEAV VNTVDISEREKVAQLRSLYK KAGLGKEKRHVTYVVAKKGV GRKVRRPAGVRGHFKVVDSR MKKDQRAQQRKEQKKKHKR |
| Post Translational Modifications | Citrullinated by PADI4. |
| Function | RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system. RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5. Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine. Recruited to HIV-1 RNA via interaction with TARBP2/TRBP. |
| Protein Name | Pre-Rrna 2'-O-Ribose Rna Methyltransferase Ftsj3Protein Ftsj Homolog 3Putative Rrna Methyltransferase 3 |
| Database Links | Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Pre-Rrna 2'-O-Ribose Rna Methyltransferase Ftsj3 antibodyAnti-Protein Ftsj Homolog 3 antibodyAnti-Putative Rrna Methyltransferase 3 antibodyAnti-FTSJ3 antibodyAnti-SB92 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
