Anti-FAF2 antibody (176-393) (STJ11103328)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FAF2 (176-393) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FAF2 |
| Gene ID | 23197 |
| Uniprot ID | FAF2_HUMAN |
| Immunogen Region | 176-393 |
| Immunogen Sequence | YLHGDDHQDSDEFCRNTLCA PEVISLINTRMLFWACSTNK PEGYRVSQALRENTYPFLAM IMLKDRRMTVVGRLEGLIQP DDLINQLTFIMDANQTYLVS ERLEREERNQTQVLRQQQDE AYLASLRADQEKERKKREER ERKRRKEEEVQQQKLAEERR RQNLQEEKERKLECLPPEPS PDDPESVKIIFKLPNDSRVE RRFHFSQSLTVIHDFLFS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 176-393 of human FAF2 (NP_055428.1). |
Additional Info
| Tissue Specificity | Broadly expressed, with highest levels in brain. |
| Function | Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis. Involved in stress granule disassembly: associates with ubiquitinated G3BP1 in response to heat shock, thereby promoting interaction between ubiquitinated G3BP1 and VCP, followed by G3BP1 extraction from stress granules and stress granule disassembly. |
| Protein Name | Fas-Associated Factor 2Ubx Domain-Containing Protein 3bUbx Domain-Containing Protein 8 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8980692 |
| Cellular Localisation | CytoplasmLipid DropletEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Fas-Associated Factor 2 antibodyAnti-Ubx Domain-Containing Protein 3b antibodyAnti-Ubx Domain-Containing Protein 8 antibodyAnti-FAF2 antibodyAnti-ETEA antibodyAnti-KIAA0887 antibodyAnti-UBXD8 antibodyAnti-UBXN3B antibody |
Information sourced from Uniprot.org