| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FAF2 |
| Gene ID: | 23197 |
| Uniprot ID: | FAF2_HUMAN |
| Immunogen Region: | 176-393 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 176-393 of human FAF2 (NP_055428.1). |
| Immunogen Sequence: | YLHGDDHQDSDEFCRNTLCA PEVISLINTRMLFWACSTNK PEGYRVSQALRENTYPFLAM IMLKDRRMTVVGRLEGLIQP DDLINQLTFIMDANQTYLVS ERLEREERNQTQVLRQQQDE AYLASLRADQEKERKKREER ERKRRKEEEVQQQKLAEERR RQNLQEEKERKLECLPPEPS PDDPESVKIIFKLPNDSRVE RRFHFSQSLTVIHDFLFS |
| Tissue Specificity | Broadly expressed, with highest levels in brain. |
| Function | Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis. Involved in stress granule disassembly: associates with ubiquitinated G3BP1 in response to heat shock, thereby promoting interaction between ubiquitinated G3BP1 and VCP, followed by G3BP1 extraction from stress granules and stress granule disassembly. |
| Protein Name | Fas-Associated Factor 2 Ubx Domain-Containing Protein 3b Ubx Domain-Containing Protein 8 |
| Database Links | Reactome: R-HSA-6798695 Reactome: R-HSA-8980692 |
| Cellular Localisation | Cytoplasm Lipid Droplet Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Fas-Associated Factor 2 antibody Anti-Ubx Domain-Containing Protein 3b antibody Anti-Ubx Domain-Containing Protein 8 antibody Anti-FAF2 antibody Anti-ETEA antibody Anti-KIAA0887 antibody Anti-UBXD8 antibody Anti-UBXN3B antibody |
Information sourced from Uniprot.org