| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:3000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EHD2 |
| Gene ID: | 30846 |
| Uniprot ID: | EHD2_HUMAN |
| Immunogen Region: | 244-543 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 244-543 of human EHD2 (NP_055416.2). |
| Immunogen Sequence: | VGTPEVLRVYIGSFWSQPLL VPDNRRLFELEEQDLFRDIQ GLPRHAALRKLNDLVKRARL VRVHAYIISYLKKEMPSVFG KENKKKQLILKLPVIFAKIQ LEHHISPGDFPDCQKMQELL MAHDFTKFHSLKPKLLEALD EMLTHDIAKLMPLLRQEELE STEVGVQGGAFEGTHMGPFV ERGPDEAMEDGEEGSDDEAE WVVTKDKSKYDEIFYNLAPA DGKLSGSKAKTWMVGTKLP |
| Tissue Specificity | Highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle. |
| Function | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane. |
| Protein Name | Eh Domain-Containing Protein 2 Past Homolog 2 |
| Database Links | Reactome: R-HSA-983231 |
| Cellular Localisation | Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Membrane Caveola Endosome Membrane Cytoplasm Cytosol Colocalizes With Glut4 In Intracellular Tubulovesicular Structures That Are Associated With Cortical F-Actin Colocalizes With Fer1l5 At Plasma Membrane In Myoblasts And Myotubes |
| Alternative Antibody Names | Anti-Eh Domain-Containing Protein 2 antibody Anti-Past Homolog 2 antibody Anti-EHD2 antibody Anti-PAST2 antibody |
Information sourced from Uniprot.org