Anti-EHD2 antibody (244-543) (STJ114811)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal EHD2 (244-543) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:3000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EHD2 |
| Gene ID | 30846 |
| Uniprot ID | EHD2_HUMAN |
| Immunogen Region | 244-543 |
| Immunogen Sequence | VGTPEVLRVYIGSFWSQPLL VPDNRRLFELEEQDLFRDIQ GLPRHAALRKLNDLVKRARL VRVHAYIISYLKKEMPSVFG KENKKKQLILKLPVIFAKIQ LEHHISPGDFPDCQKMQELL MAHDFTKFHSLKPKLLEALD EMLTHDIAKLMPLLRQEELE STEVGVQGGAFEGTHMGPFV ERGPDEAMEDGEEGSDDEAE WVVTKDKSKYDEIFYNLAPA DGKLSGSKAKTWMVGTKLP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 244-543 of human EHD2 (NP_055416.2). |
Additional Info
| Tissue Specificity | Highly expressed in heart and moderately expressed in placenta, lung, and skeletal muscle. |
| Function | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane. |
| Protein Name | Eh Domain-Containing Protein 2Past Homolog 2 |
| Database Links | Reactome: R-HSA-983231 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideMembraneCaveolaEndosome MembraneCytoplasmCytosolColocalizes With Glut4 In Intracellular Tubulovesicular Structures That Are Associated With Cortical F-ActinColocalizes With Fer1l5 At Plasma Membrane In Myoblasts And Myotubes |
| Alternative Antibody Names | Anti-Eh Domain-Containing Protein 2 antibodyAnti-Past Homolog 2 antibodyAnti-EHD2 antibodyAnti-PAST2 antibody |
Information sourced from Uniprot.org