Anti-EFEMP1 antibody (18-493 aa) [R01-7C7] (STJA0012357)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human EFEMP1/Fibulin-3
General Information
| Short Description | Rabbit monoclonal anti-EFEMP1 (18-493 aa) for use in WB, IHC-P and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-7C7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | EFEMP1 |
| Gene ID | 2202 |
| Uniprot ID | FBLN3_HUMAN |
| Immunogen | Recombinant protein of human EFEMP1/Fibulin-3 |
| Immunogen Region | 18-493 aa |
Additional Info
| Tissue Specificity | In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina. |
| Function | Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. |
| Protein Name | Egf-Containing Fibulin-Like Extracellular Matrix Protein 1Extracellular Protein S1-5Fibrillin-Like ProteinFibulin-3Fibl-3 |
| Database Links | Reactome: R-HSA-2129379 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixLocalizes To The Lamina Propria Underneath The Olfactory Epithelium |
| Alternative Antibody Names | Anti-Egf-Containing Fibulin-Like Extracellular Matrix Protein 1 antibodyAnti-Extracellular Protein S1-5 antibodyAnti-Fibrillin-Like Protein antibodyAnti-Fibulin-3 antibodyAnti-Fibl-3 antibodyAnti-EFEMP1 antibodyAnti-FBLN3 antibodyAnti-FBNL antibody |
Information sourced from Uniprot.org