| Tissue Specificity | Highly expressed in muscle and heart. Over-expressed in pancreatic and breast cancers. |
| Post Translational Modifications | Phosphorylated predominantly by CK2 on two serine-containing clusters.involved in cell cycle regulation activity. |
| Function | Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing. Participates together with DDX39A in mRNA nuclear export. |
| Protein Name | Protein Ecdysoneless HomologHuman Suppressor Of Gcr TwoHsgt1 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusPredominantly Is Located In The Cytoplasm |
| Alternative Antibody Names | Anti-Protein Ecdysoneless Homolog antibodyAnti-Human Suppressor Of Gcr Two antibodyAnti-Hsgt1 antibodyAnti-ECD antibody |
Information sourced from Uniprot.org
