| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Deoxyribonuclease-2-alpha is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DNASE2 |
| Gene ID: |
1777 |
| Uniprot ID: |
DNS2A_HUMAN |
| Specificity: |
This antibody detects endogenous levels of DNASE2 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human DNASE2 |
| Post Translational Modifications | Glycosylated. Genetic variations that affect N-glycosylation sites reduce activity, but enzymatic deglycosylation has no effect. |
| Function | Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells. |
| Protein Name | Deoxyribonuclease-2-AlphaAcid DnaseDeoxyribonuclease Ii AlphaDnase Ii AlphaLysosomal Dnase IiR31240_2 |
| Database Links | Reactome: R-HSA-432720 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Deoxyribonuclease-2-Alpha antibodyAnti-Acid Dnase antibodyAnti-Deoxyribonuclease Ii Alpha antibodyAnti-Dnase Ii Alpha antibodyAnti-Lysosomal Dnase Ii antibodyAnti-R31240_2 antibodyAnti-DNASE2 antibodyAnti-DNASE2A antibodyAnti-DNL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
