Anti-DNASE2 antibody (STJA0008014)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human DNASE2
General Information
| Short Description | Rabbit polyclonal anti-Deoxyribonuclease-2-alpha for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DNASE2 |
| Gene ID | 1777 |
| Uniprot ID | DNS2A_HUMAN |
| Immunogen | Synthesized peptide derived from human DNASE2 |
| Specificity | This antibody detects endogenous levels of DNASE2 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Glycosylated. Genetic variations that affect N-glycosylation sites reduce activity, but enzymatic deglycosylation has no effect. |
| Function | Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells. |
| Protein Name | Deoxyribonuclease-2-AlphaAcid DnaseDeoxyribonuclease Ii AlphaDnase Ii AlphaLysosomal Dnase IiR31240_2 |
| Database Links | Reactome: R-HSA-432720 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Deoxyribonuclease-2-Alpha antibodyAnti-Acid Dnase antibodyAnti-Deoxyribonuclease Ii Alpha antibodyAnti-Dnase Ii Alpha antibodyAnti-Lysosomal Dnase Ii antibodyAnti-R31240_2 antibodyAnti-DNASE2 antibodyAnti-DNASE2A antibodyAnti-DNL2 antibody |
Information sourced from Uniprot.org