| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Deoxyribonuclease-2-alpha is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DNASE2 |
| Gene ID: | 1777 |
| Uniprot ID: | DNS2A_HUMAN |
| Specificity: | This antibody detects endogenous levels of DNASE2 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human DNASE2 |
| Post Translational Modifications | Glycosylated. Genetic variations that affect N-glycosylation sites reduce activity, but enzymatic deglycosylation has no effect. |
| Function | Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells. |
| Protein Name | Deoxyribonuclease-2-Alpha Acid Dnase Deoxyribonuclease Ii Alpha Dnase Ii Alpha Lysosomal Dnase Ii R31240_2 |
| Database Links | Reactome: R-HSA-432720 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Deoxyribonuclease-2-Alpha antibody Anti-Acid Dnase antibody Anti-Deoxyribonuclease Ii Alpha antibody Anti-Dnase Ii Alpha antibody Anti-Lysosomal Dnase Ii antibody Anti-R31240_2 antibody Anti-DNASE2 antibody Anti-DNASE2A antibody Anti-DNL2 antibody |
Information sourced from Uniprot.org