Anti-DHCR24 antibody (STJA0006968)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human DHCR24
General Information
| Short Description | Rabbit polyclonal anti-Delta24-sterol reductase for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DHCR24 |
| Gene ID | 1718 |
| Uniprot ID | DHC24_HUMAN |
| Immunogen | Synthesized peptide derived from human DHCR24 |
| Specificity | This antibody detects endogenous levels of DHCR24 at Human, Mouse, Rat |
Additional Info
| Function | Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis. |
| Protein Name | Delta(24-Sterol Reductase24-Dehydrocholesterol Reductase3-Beta-Hydroxysterol Delta-24-ReductaseDiminuto/Dwarf1 HomologSeladin-1 |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-6807047Reactome: R-HSA-6807062 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Delta(24-Sterol Reductase antibodyAnti-24-Dehydrocholesterol Reductase antibodyAnti-3-Beta-Hydroxysterol Delta-24-Reductase antibodyAnti-Diminuto/Dwarf1 Homolog antibodyAnti-Seladin-1 antibodyAnti-DHCR24 antibodyAnti-KIAA0018 antibody |
Information sourced from Uniprot.org