Anti-DGUOK antibody (40-277) (STJ28978)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal DGUOK (40-277) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | DGUOK |
| Gene ID | 1716 |
| Uniprot ID | DGUOK_HUMAN |
| Immunogen Region | 40-277 |
| Immunogen Sequence | RLSIEGNIAVGKSTFVKLLT KTYPEWHVATEPVATWQNIQ AAGTQKACTAQSLGNLLDMM YREPARWSYTFQTFSFLSRL KVQLEPFPEKLLQARKPVQI FERSVYSDRYIFAKNLFENG SLSDIEWHIYQDWHSFLLWE FASRITLHGFIYLQASPQVC LKRLYQRAREEEKGIELAYL EQLHGQHEAWLIHKTTKLHF EALMNIPVLVLDVNDDFSEE VTKQEDLMREVNTFVKNL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 40-277 of human DGUOK (NP_550438.1). |
Additional Info
| Tissue Specificity | Ubiquitous. Highest expression in muscle, brain, liver and lymphoid tissues. |
| Function | Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents. |
| Protein Name | Deoxyguanosine Kinase - MitochondrialDeoxyadenosine Kinase - Mitochondrial |
| Database Links | Reactome: R-HSA-74217 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Deoxyguanosine Kinase - Mitochondrial antibodyAnti-Deoxyadenosine Kinase - Mitochondrial antibodyAnti-DGUOK antibodyAnti-DGK antibody |
Information sourced from Uniprot.org