| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CYTH1 |
| Gene ID: | 9267 |
| Uniprot ID: | CYH1_HUMAN |
| Immunogen Region: | 1-70 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human CYTH1 (NP_004753.1). |
| Immunogen Sequence: | MEEDDSYVPSDLTAEERQEL ENIRRRKQELLADIQRLKDE IAEVANEIENLGSTEERKNM QRNKQVAMGR |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Ubiquitinated by SCF(FBXW11) E3 ubiquitin-protein ligase complex. Ubiquitination induces proteasomal degradation. |
| Function | Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. |
| Protein Name | Cytohesin-1 Ph - Sec7 And Coiled-Coil Domain-Containing Protein 1 Sec7 Homolog B2-1 |
| Database Links | Reactome: R-HSA-6811438 |
| Cellular Localisation | Cell Membrane Peripheral Membrane Protein Cytoplasm Cytosol Cell Junction Tight Junction Adherens Junction Colocalized With Tjp1 During Epithelial Polarization |
| Alternative Antibody Names | Anti-Cytohesin-1 antibody Anti-Ph - Sec7 And Coiled-Coil Domain-Containing Protein 1 antibody Anti-Sec7 Homolog B2-1 antibody Anti-CYTH1 antibody Anti-D17S811E antibody Anti-PSCD1 antibody |
Information sourced from Uniprot.org