Anti-CYTH1 antibody (1-70) (STJ117546)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CYTH1 (1-70) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CYTH1 |
| Gene ID | 9267 |
| Uniprot ID | CYH1_HUMAN |
| Immunogen Region | 1-70 |
| Immunogen Sequence | MEEDDSYVPSDLTAEERQEL ENIRRRKQELLADIQRLKDE IAEVANEIENLGSTEERKNM QRNKQVAMGR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human CYTH1 (NP_004753.1). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Ubiquitinated by SCF(FBXW11) E3 ubiquitin-protein ligase complex. Ubiquitination induces proteasomal degradation. |
| Function | Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity. |
| Protein Name | Cytohesin-1Ph - Sec7 And Coiled-Coil Domain-Containing Protein 1Sec7 Homolog B2-1 |
| Database Links | Reactome: R-HSA-6811438 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmCytosolCell JunctionTight JunctionAdherens JunctionColocalized With Tjp1 During Epithelial Polarization |
| Alternative Antibody Names | Anti-Cytohesin-1 antibodyAnti-Ph - Sec7 And Coiled-Coil Domain-Containing Protein 1 antibodyAnti-Sec7 Homolog B2-1 antibodyAnti-CYTH1 antibodyAnti-D17S811E antibodyAnti-PSCD1 antibody |
Information sourced from Uniprot.org