Anti-CYRIB antibody (STJA0007514)

SKU:
STJA0007514
$64.80 - $340.20
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-CYFIP-related Rac1 interactor B is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CYRIB
Gene ID: 51571
Uniprot ID: CYRIB_HUMAN
Specificity: This antibody detects endogenous levels of FAM49B at Human, Mouse
Immunogen: Synthesized peptide derived from human FAM49B
Function Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling. Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization. Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry. Restricts also infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes. Involved in the regulation of mitochondrial dynamics and oxidative stress.
Protein Name Cyfip-Related Rac1 Interactor B
L1
Database Links Reactome: R-HSA-114608
Cellular Localisation Membrane
Lipid-Anchor
Mitochondrion
Alternative Antibody Names Anti-Cyfip-Related Rac1 Interactor B antibody
Anti-L1 antibody
Anti-CYRIB antibody
Anti-CYRI antibody
Anti-FAM49B antibody
Anti-BM-009 antibody

Information sourced from Uniprot.org

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