Anti-CYRIB antibody (STJA0007514)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human FAM49B
General Information
| Short Description | Rabbit polyclonal anti-CYFIP-related Rac1 interactor B for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CYRIB |
| Gene ID | 51571 |
| Uniprot ID | CYRIB_HUMAN |
| Immunogen | Synthesized peptide derived from human FAM49B |
| Specificity | This antibody detects endogenous levels of FAM49B at Human, Mouse |
Additional Info
| Function | Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling. Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization. Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry. Also restricts infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes. Involved in the regulation of mitochondrial dynamics and oxidative stress. |
| Protein Name | Cyfip-Related Rac1 Interactor BL1 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | MembraneLipid-AnchorMitochondrion |
| Alternative Antibody Names | Anti-Cyfip-Related Rac1 Interactor B antibodyAnti-L1 antibodyAnti-CYRIB antibodyAnti-CYRI antibodyAnti-FAM49B antibodyAnti-BM-009 antibody |
Information sourced from Uniprot.org