Name: Anti-CYP8B1 antibody (371-420 aa) (STJ92607)
SKU: STJ92607
Availability: InStock

Anti-CYP8B1 antibody (371-420 aa) (STJ92607)

SKU:

STJ92607

£49.00 - £261.00

Short Description :	Rabbit polyclonal anti-7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (371-420 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications:	WB/IHC/IF/ELISA
Host:	Rabbit
Reactivity:	Human/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality :	Polyclonal
Isotype:	IgG
Conjugation:	Unconjugated
Concentration:	1 mg/mL
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:40000 IF 1:50-200
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CYP8B1
Gene ID:	1582
Uniprot ID:	CP8B1_HUMAN
Immunogen:	The antiserum was produced against synthesized peptide derived from the human Cytochrome P450 8B1 at the amino acid range 371-420
Immunogen Region:	371-420 aa
Specificity:	CYP8B1 Polyclonal Antibody detects endogenous levels of CYP8B1 protein.

Function	A cytochrome P450 monooxygenase involved in primary bile acid biosynthesis. Catalyzes the 12alpha-hydroxylation of 7alpha-hydroxy-4-cholesten-3-one, an intermediate metabolite in cholic acid biosynthesis. Controls biliary balance of cholic acid and chenodeoxycholic acid, ultimately regulating the intestinal absorption of dietary lipids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH--hemoprotein reductase).
Protein Name	7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase 7-Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase Cypviiib1 Cytochrome P450 8b1 Sterol 12-Alpha-Hydroxylase
Database Links	Reactome: R-HSA-193368 Reactome: R-HSA-193775 Reactome: R-HSA-193807 Reactome: R-HSA-197264 Reactome: R-HSA-211979 Reactome: R-HSA-211994 Reactome: R-HSA-2162123
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Membrane Protein Microsome Membrane
Alternative Antibody Names	Anti-7-Alpha-Hydroxycholest-4-En-3-One 12-Alpha-Hydroxylase antibody Anti-7-Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase antibody Anti-Cypviiib1 antibody Anti-Cytochrome P450 8b1 antibody Anti-Sterol 12-Alpha-Hydroxylase antibody Anti-CYP8B1 antibody Anti-CYP12 antibody

Information sourced from Uniprot.org

Anti-CYP8B1 antibody (371-420 aa) (STJ92607)

General Information

Model	Name	Host	Clonality	Reactivity	Application
STJ93590	Anti-MAP4K1 antibody (371-420 aa) (STJ93590)	Rabbit	Polyclonal	Human/Mouse	WB/IHC/IF/ELISA
STJ98631	Anti-C8B antibody (371-420 aa) (STJ98631)	Rabbit	Polyclonal	Human/Rat	WB/ELISA
STJ91848	Anti-VWA5A antibody (371-420 aa) (STJ91848)	Rabbit	Polyclonal	Human/Rat/Mouse	WB/ELISA
STJ92369	Anti-SLC28A2 antibody (371-420 aa) (STJ92369)	Rabbit	Polyclonal	Human/Mouse/Rat	WB/IHC/IF/ELISA
STJ93678	Anti-IL13RA1 antibody (371-420 aa) (STJ93678)	Rabbit	Polyclonal	Human/Mouse/Rat	WB/IHC/IF/ELISA