| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-CKLF-like MARVEL transmembrane domain-containing protein 4 (161-210 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC-P 1:100-300ELISA 1:20000IF 1:100-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CMTM4 |
| Gene ID: | 146223 |
| Uniprot ID: | CKLF4_HUMAN |
| Immunogen Region: | 161-210 aa |
| Specificity: | CMTM4 Polyclonal Antibody detects endogenous levels of CMTM4 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CKLF4 at the amino acid range 161-210 |
| Function | Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation. |
| Protein Name | Cklf-Like Marvel Transmembrane Domain-Containing Protein 4Chemokine-Like Factor Superfamily Member 4 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cklf-Like Marvel Transmembrane Domain-Containing Protein 4 antibodyAnti-Chemokine-Like Factor Superfamily Member 4 antibodyAnti-CMTM4 antibodyAnti-CKLFSF4 antibody |
Information sourced from Uniprot.org